Protease Inhibitors and Phosphatase Inhibitors
Invivogen Pam3CSK4 Synthetic triacylated lipopeptide; TLR2/TLR1 agonist, 1mg
Pam3CSK4 TLR2 Ligands, Synthetic tripalmitoylated lipopeptide, Working Concentration: 100 to 300ng/mL, Quantity; 1mg
Sigma Aldrich Fine Chemicals Biosciences cOmplete Protease Inhibitor Cocktail, 3 x 20 tablets
cOmplete Protease Inhibitor Tablets inhibit a broad spectrum of serine, cysteine, and metalloproteases, as well as calpains. Due to the optimized composition of the tablets, they show excellent inhibition effects, and are well suited for the protection of proteins isolated from animal tissues, plants, yeast, and bacteria. cOmplete tablets contain EDTA and both irreversible and reversible protease inhibitors.
Cayman Chemical Aurora A InhIbItr I 1mg
A potent and selective inhibitor of Aurora A kinase (IC50s = 3.4 and 3,400 nM for Aurora A and Aurora B, respectively); prevents centrosome separation and reduces phosphorylated Aurora A, but not phosphorylated histone H3, levels at the centrosomes; reduces the proliferation of HCT116 and HT-29 colorectal carcinoma cells in vitro (IC50s = 0.19 and 2.9 μM, respectively)
Cayman Chemical AZ1 USP2528 InhIbItr 25mg
A dual inhibitor of USP25 and USP28 (IC50s = 0.7 and 0.6 µM, respectively); selective for USP25 and USP28 over USP2a (IC50 = >100 µM), a panel of 22 other deubiquitinases at 10 µM, and a panel of eight caspases and cathepsins at 30 µM; induces degradation of c-Myc in HCT116 cells, an effect that can be reversed by MG132; decreases the viability of several cancer cell lines (EC50s = 9.8-33.5 µM)
Cayman Chemical CathepsIn G InhIbItr I 5mg
A cathepsin G inhibitor (IC50 = 53 nM); selective for cathepsin G over thrombin, Factor Xa, Factor IXa, plasmin, trypsin, and PR3 (IC50s = >100 µM for all), but also weakly inhibits chymotrypsin; inhibits cathepsin G-induced activation of IL-36 in neutrophil degranulates at 10 µM; reduces CD4+ T cell-induced secretion of IFN-γ and IL-17 in B cells incubated with TTC and also reduces TTC presentation in B cells at 10 µM; decreases the size of neuromyelitis optica lesions and reduces the number of perivascular neutrophils when used in combination with sivelestat in a mouse model of IgG-induced brain injury at 5 UG/animal
Cayman Chemical GSK3 InhIbItr VIII 10mg
A selective, ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM); demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death
Selleck Chemical LLC GSK2830371 10mg 1404456-53-6
GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam E-64d (Alo x istatin), cathepsin B and L inhibitor, 1MG
MW 342.4 Da, Purity >98%. Irreversible cell-permeable cathepsin B and L inhibitor. Inhibits calpain. Inhibits autophagy. Inhibits platelet proteolysis. Reduces brain amyloid-β levels. Shows neuroprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Research Products International Corp RPI (-)-p-Bromotetramisole Oxalate, 5 Milligrams
Potent alkaline phosphate inhibitor. Mimics the action of orthovanadate in the potentiation of fluorouracil antiproliferative activity. Cell permeable.
Selleck Chemical LLC LB-100 5mg 1026680-07-8
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 ?M and 3.87 ?M in BxPc-3 and Panc-1 cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC HY-112136 10mg Medchemexpress, TAO Kinase inhibitor 1 CAS:850467-66-2 Purity:>98%
Medchemexpress, HY-112136 10mg TAO Kinase inhibitor 1 CAS:850467-66-2 TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ThIordoxIn Rducts 1 InhIb 10mg
An irreversible inhibitor of TrxR1 (IC50 = 0.012 µM); inhibits TrxR1-induced reduction of Trx1 in a cell-free assay (IC50 = 4.3 µM); reduces the mitochondrial oxygen consumption rate in HCT116 cells at 10 µM; increases the intracellular levels of hydrogen peroxide in FaDu cancer cells in a time- and concentration-dependent manner; decreases the viability of FaDu cells (IC50 = 0.72 µM); decreases tumor growth in a FaDu HNSCC mouse xenograft model at 10 mg/kg twice per day; induces apoptosis in a FaDu HNSCC mouse xenograft model at 5 mg/kg daily; toxic to S. mansoni adult worms (LD50 = 10.07 µM)
Selleck Chemical LLC Pacritinib (SB1518) 5mg 937272-79-2
Pacritinib (SB1518) is a potent and selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3) with IC50s of 23 and 22 nM in cell-free assays, respectively. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.